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These specimens all show pathological changes associated with Paget’s Disease.

B0146: B82 EQ 6/7

Partial frontal

There is marked thinning of the inner and outer cortical layers, with extensive surface porosity on all surfaces of the bone fragment.  There is considerable thickening of the cranial vault by endosteal and subperiosteal new bone formation that is highly irregular, disorganised, and fills the diploic space.  The grooves for the meningeal vessels are particularly deep.   At its thickest, the fragment measures 23mm endo- to ectocranially.

 

B0148: Hull Magistrates Court 1965

Left femur

The shaft and the greater and lesser trochanters are considerably thickened by a deposition of highly disorganised new bone, especially on the medial and lateral surfaces, with substantial narrowing of the medullary cavity.  The external surface of the bone is highly disorganised with pitting and porosity.  There are no changes to the surface of the femoral neck or head, with the trabeculae of the head remaining normal.

 

B0150: Lincoln SUS ’96 116

Right os coxae

The entire bone is considerably thickened by a deposition of highly porous and pitted disorganised new compact bone mixed with irregular striations of compact bone on all non-articular surfaces.  Two small patches of irregular woven bone are located on the lateral surface near the inferior gluteal line.  The superior margin of the acetabulum has been extended by osteophytic growth. Within the acetabulum are multiple destructive lesions that have irregular sharp margins, many of which perforate into the trabeculae. On the superolateral surface in the acetabulum is a large area of eburnation.

 

B0733, B0734, B0738: Hereford Cathedral (HE93A) 3051

Left tibia

There is considerable thickening of the proximal half of the shaft with deposition of highly disorganised subperiosteal new compact bone, especially on the anterior surface.  Narrowing of the medullary cavity is evident.  The external surface of the bone appears highly disorganised and heavily pitted.

Left radius

There is considerable thickening of the whole shaft with deposition of highly disorganised new compact bone.  Extensive narrowing of the medullary cavity is evident in cross-section and on the radiograph.  The external surface of the bone is highly disorganised and heavily pitted.  The articular surfaces remain unaffected.  However, on the lateral side of the head is a well demarcated lesion c.11mm anteroposterior x 4mm proximodistal at its greatest.  The margins of this lesion are sharp and irregular and the floor surface is irregular with multiple large pits.

Right scapula

There is considerable thickening of the whole bone, with deposition of highly disorganised new compact bone, especially along the spine.  The external surface of the bone appears to be made of highly disorganised and heavily pitted new bone.   The glenoid articular surface remains unaffected by new bone growth.  However, there are four large pits in the area adjacent to the inferior border.

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